Abstract

Cocaine addiction remains a persistent issue with limited treatment options. Research into neurobiological pathways involved in addiction has highlighted the metabotropic glutamate receptor subtype 5 (mGluR5) as a potential target for therapeutic intervention. This study investigates the role of mGluR5 in cocaine addiction using mouse models, assessing behavioral, neurochemical, and molecular changes associated with mGluR5 modulation. Results indicate that mGluR5 activity is closely linked with cocaine-related reward and relapse mechanisms, suggesting that mGluR5 antagonism may reduce cocaine-seeking behavior. The findings contribute to understanding addiction neurobiology and support further research on mGluR5 as a target for treating cocaine addiction.