Hippocampal Sclerosis and Epilepsy in Elderly Population | OMICS International| Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2017, Vol 7(5): 384
  • DOI: 10.4172/2161-0460.1000384

Hippocampal Sclerosis and Epilepsy in Elderly Population

Tuomas Rauramaa1,2,3*, Alina Solomon4,5, Maria Pikkarainen2,3, Reetta Kälviäinen6,7 and Irina Alafuzoff8,9
1Department of Pathology, Kuopio University Hospital, , Finland
2Institute of Clinical Medicine, Unit of Pathology, University of Eastern Finland, Finland
3Institute of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Finland
4Institute of Clinical Medicine/Neurology, University of Eastern Finland, Finland
5Center for Alzheimer Research, Karolinska Institutet, , Huddinge, Sweden
6Department of Neurology, Kuopio University Hospital, , Finland
7Department of Neurology, School of Medicine, University of Eastern Finland, Finland
8Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden
9Department of Pathology and Cytology, Uppsala University Hospital, , Sweden
*Corresponding Author : Tuomas Rauramaa, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 1777 FIN-70211, Kuopio, Finland, Tel: +358445346179, Email: [email protected]

Received Date: Nov 15, 2017 / Accepted Date: Oct 06, 2017 / Published Date: Oct 13, 2017


Objective: In temporal lobe epilepsy, hippocampal sclerosis (HS) and Alzheimer’s disease (AD) pathological alterations in the hippocampus are frequently observed. Methods: We assessed the clinicopathological characteristics of 30 aged subjects with HS originating from a large unselected autopsy cohort including 1,388 individuals. Results: Overall, in 22 subjects AD related pathology and in 17 subjects TDP43 pathology, from mild, moderate to severe was seen. Five subjects out of 30 (17%) with HS had epilepsy. Conclusion: A higher percentage compared to the reported prevalence of epilepsy in 0.6 percent of the adult population was observed, but more post mortem studies are urgently needed to investigate the pathological substrate for epilepsy in AD.

Keywords: Hippocampus; Postmortem; Hippocampal sclerosis; Epilepsy; Alzheimer

Citation: Rauramaa T, Solomon A, Pikkarainen M, Kälviäinen R, Alafuzoff I, et al. (2017) Hippocampal Sclerosis and Epilepsy in Elderly Population. J Alzheimers Dis Parkinsonism 7: 384. Doi: 10.4172/2161-0460.1000384

Copyright: © 2017 Rauramaa T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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