Journal of Meningitis
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  • Research Article   
  • J Meningitis 2015, Vol 1(1)
  • DOI: 10.4172/2572-2050.1000102

Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease

Zinchenko AA1, Alliluev AP2, Serova OP1, Gordeeva EA1, Zhigis LS1*, Zueva VS1, Razgulyaeva OA1, Melikhova TD1, Nokel EA1, Drozhzhina E Yu1, Kotelnikova OV1 and Rumsh LD1
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, , Miklukho-Maklaya ul. 16/10, Moscow 117997, Russia
2Peoples' Friendship University of Russia, (Medical Faculty), Russia
*Corresponding Author : Zhigis LS, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,Russian Academy of Sciences, Miklukho-Maklaya Ul. 16/10, Moscow 117997, Russia, Tel: (495)3305638, Email: zhigis@mail.ibch.ru

Received Date: Oct 07, 2015 / Accepted Date: Dec 08, 2015 / Published Date: Dec 15, 2015

Abstract

Recombinant proteins (M1K2–N963-LEH6, MA28–N963-LEH6 and ME135–H328-LEH6) have been created on the basis of the genome sequence of IgA1 protease of N. meningitidis serogroup B strain H44/76. It is revealed that, similarly to the native enzyme isolated earlier from N. meningitidis serogroup A strain A208, these proteins induce formation of animal protection against the infection with the virulent strain of meningococcus serogroup B. It is shown that these compounds are promising as a basis for a polyvalent anti-meningococcal vaccine.

Keywords: IgA1 protease; Recombinant proteins; Meningococcus; Immunogenicity; Protectivity

Citation: Zinchenko AA, Alliluev AP, Serova OP, Gordeeva EA, Zhigis LS, et al. (2015) Immunogenic and Protective Properties of Recombinant Proteins Based on Meningococcal Iga1 Protease. J Meningitis 1:102. Doi: 10.4172/2572-2050.1000102

Copyright: ©2015 Zinchenko AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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