alexa In vitro Inhibition of Leishmania braziliensis Promastigotes Growth by aFluconazole Microemulsion
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
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Research Article

In vitro Inhibition of Leishmania braziliensis Promastigotes Growth by aFluconazole Microemulsion

Claudia Salerno1, Adriana M Carlucci1, Susana Gorzalczany2 and Carlos Bregni1*
1Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
2Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Corresponding Author : Carlos Bregni
Department of Pharmaceutical Technology
Faculty of Pharmacy and Biochemistry
University of Buenos Aires, Junin 956, Buenos Aires, Argentina
Tel: +54-11-4964-8271
E-mail: [email protected]; [email protected]
Received May 28, 2014; Accepted July 02, 2014; Published July 05, 2014
Citation: Salerno C, Carlucci AM, Gorzalczany S, Bregni C (2014) In vitro Inhibition of Leishmania braziliensis Promastigotes Growth by a Fluconazole Microemulsion. J Mol Pharm Org Process Res 2:115. doi: 10.4172/2329- 9053.1000115
Copyright: © 2014 Salerno C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Cutaneous leishmaniasis (CL) is the most prevalent form of the disease caused by the parasites Leishmania. However, effective topical treatments for the disease are lacking. Fluconazole (FLZ) is an antifungal agent that inhibits a key enzyme for the production of ergosterol, the main sterol in membranes of fungi and parasites. An in vitro evaluation of antileishmanial activity of a microemulsion intended for topical use, with FLZ as active pharmaceutical ingredient, was performed.   The formulation effectively inhibited L. braziliensis promastigotes growth. This study provides baseline data about the efficacy of FLZ microemulsion on L. braziliensis promastigotes. Previous reports had shown poor activity of the drug, so this result highlighted the role of the vehicle.   Although further work is needed, this semisolid dosage form could be useful for the local treatment of CL in the New World. It is also interesting to mention the importance of repositioning well-known drugs for new uses to offer treatments more quickly, particularly for this disease that greatly affects public health of poor regions.

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