Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality worldwide, affecting both adults and children. The rising prevalence of MRSA infections necessitates effective treatment strategies to combat this public health challenge. This guideline aims to provide comprehensive, evidence-based recommendations for the diagnosis and treatment of MRSA infections in adults and children, with a focus on optimizing clinical outcomes and reducing antibiotic resistance. A thorough review of the existing literature, clinical trials, and expert consensus was conducted to develop these guidelines. The recommendations are categorized based on the type of MRSA infection, including skin and soft tissue infections, pneumonia, and bloodstream infections. Key recommendations include the appropriate use of antimicrobial therapies, strategies for de-escalation based on susceptibility testing, and considerations for adjunctive therapies. The guidelines emphasize the importance of infection control measures and the role of multidisciplinary teams in managing complex cases. These guidelines provide healthcare professionals with the necessary tools to effectively manage MRSA infections in both adults and children, aiming to improve patient outcomes and reduce the burden of antibiotic resistance.