alexa Invasive Lobular Carcinoma of the Breast: The Use of Radiological Appearance to Classify Tumor Subtypes for Better Prediction of Long-Term Outcome | OMICS International| Abstract
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Journal of Clinical & Experimental Pathology
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  • Review Article   
  • J Clin Exp Pathol 2014, Vol 4(4): 179
  • DOI: 10.4172/2161-0681.1000179

Invasive Lobular Carcinoma of the Breast: The Use of Radiological Appearance to Classify Tumor Subtypes for Better Prediction of Long-Term Outcome

Tabár L1, Dean PB2*, Chen SL3, Chen HH4, Yen AM5, Fann JC6, Chiu SY3, Smith RA7 and Duffy SW8
1Department of Mammography, Central Hospital, Falun, Sweden
2Department of Diagnostic radiology, University of Turku, Finland
3Department and Graduate Institute of Health Care Management, Chang Gung University, Taoyuan, Taiwan
4Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
5School of Oral Hygiene, Taipei Medical University, Taiwan
6Department of Health Industry Management, College of Healthcare Management, Kainan University, Taoyuan, Taiwan
7American Cancer Society, Atlanta GA, USA
8Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK
*Corresponding Author : Dean PB, MD, Department of Diagnostic radiology, University of Turku, Faculty Of Medicine, Kiinanmyllykatu 4-8, 20540 Turku, Finland, Tel: +358400969658, Fax: +35823132950, Email: [email protected]

Received Date: Mar 31, 2014 / Accepted Date: Jul 04, 2014 / Published Date: Jul 06, 2014

Abstract

We compared the survival of women diagnosed with invasive lobular carcinoma subtypes prior to and during the mammography screening era to determine the impact of early detection and treatment in an early phase upon survival according to tumor subtypes. Using mammographic tumor features, we classified 428 consecutive invasive lobular carcinoma cases of the breast into four subgroups according to their mammographic tumor features.
Life-table-based survival curves and adjusted survival curves with the accelerated failure time method were plotted to demonstrate the 14-year follow-up survival outcome with adjustment for tumor size, node status, histologic malignancy grade, tumor focality and treatment. Survival of invasive lobular carcinoma subtypes was substantially improved as a result of early detection through mammography screening and treatment in an early phase, except for the subtype presenting as architectural distortion on the mammogram, even with the use of modern therapeutic methods. There is a clear need to further develop diagnostic and management strategies to decrease mortality from the diffusely infiltrating special subtype of invasive lobular carcinoma.

Keywords: Breast neoplasms; Carcinoma; Lobular

Citation: Tabár L, Dean PB, Chen SL, Chen HH, Yen AM, et al. (2014) Invasive Lobular Carcinoma of the Breast: The Use of Radiological Appearance to Classify Tumor Subtypes for Better Prediction of Long-Term Outcome. J Clin Exp Pathol 4:179. Doi: 10.4172/2161-0681.1000179

Copyright: © 2014 Tabár L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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