ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Commentry   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(1): 425
  • DOI: 10.4172/2161-0460.1000425

Is Preservation of Cholinergic Activation a Mechanism Underlying Cognitive Reserve?

Noriyuki Matsukawa*
Department of Neurology, Nagoya City University, Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan
*Corresponding Author : Noriyuki Matsukawa, Professor and Chairman, Department of Neurology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku, Nagoya, Japan, Tel: +81-52-852-3590, Email: norim@med.nagoya-uc.ac.jp

Received Date: Feb 09, 2018 / Accepted Date: Feb 12, 2018 / Published Date: Feb 17, 2018

Abstract

The cognitive reserve, despite having abundant pathological change of Alzheimer’s disease, some patients can preserve cognitive function, is a new concept to puzzle Alzheimer’s pathogenesis. Interestingly, some recent epidemiological study has shown that diet, exercise, cognitive training and vascular risk monitoring interventions may reduce cognitive decline in at-risk elderly people in the general population. However, the mechanisms underlying this cognitive function preservation are still unknown. Our recent data suggest that differences in the persisting degree of cholinergic activity might be, at least in part, involved in the decorrelation between the extent of cognitive deterioration and AD pathological changes. This fact might raise a possibility of cholinergic modulation for hippocampal glutamatergic activity in a mechanism of “cognitive reserve”.

Citation: Matsukawa N (2018) Is Preservation of Cholinergic Activation a Mechanism Underlying Cognitive Reserve? J Alzheimers Dis Parkinsonism 8: 425. Doi: 10.4172/2161-0460.1000425

Copyright: ©2018 Matsukawa N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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