ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Hypothesis   
  • J Alzheimers Dis Parkinsonism,

Low Dose X-Ray Radiation Can Decrease the Risk of Severe COVID-19 in Individuals with the Alzheimer's Gene

Alireza Mortazavi1#, Bevelacqua JJ2#, Rohit Gosain3, Haghani M4* and SMJ Mortazavi5*
1School of Medicine, Shiraz University of Medical Sciences, Iran
2Bevelacqua Resources, Richland, USA
3Department of Hematology/Oncology, UPMC Hillman Cancer Center, USA
4Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Iran
5Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Iran
#Contributed equally to this work
*Corresponding Author (s) : Haghani M, Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran, Tel: +989173093013, Email: m.haghani4744@yahoo.com
SMJ Mortazavi, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Iran, Tel: +13234427246, Fax: +98713232-9364, Email: mortazavismj@gmail.com

Received Date: Oct 25, 2020 / Accepted Date: Nov 10, 2020 / Published Date: Jan 27, 2023

Abstract

The apolipoprotein E gene is involved in Alzheimer's disease (AD). Individuals with at least one copy of APOE e4 gene are vulnerable to AD. Some studies show an association between Alzheimer's gene and higher risk of severe COVID-19. Oxidative stress plays a key role in COVID-19. Since respiratory viral infections are linked to pathophysiological processes such as cytokine production, inflammation, and cell death, they can be associated with a redox imbalance or oxidative stress. Moreover, Low Dose X-Ray Radiation (LDXR) may play a key role in prevention of Alzheimer's disease through mechanisms such as reducing the oxidative stress. In addition, recent studies indicate that low–moderate dose ionizing radiation (LMDIR) can directly ameliorate neurodegeneration and neuroinflammation. Thus, researchers have suggested that the therapeutic effects of LMDIR in AD might be mediated by its antiinflammatory and neuroprotective effects. By combining these approaches, we believe that low dose radiation therapy (LDRT) can open new horizons in treatment of the elderly patients with the Alzheimer's gene who suffer from severe pneumonia related to COVID-19. As most victims of the COVID-19 are elderly patients, this issue becomes more important. Clinical trials are underway related to using LDXR alone or in combination with one or more drugs/treatment methods in treating COVID-19. The results of these trials should determine the optimum LDRT parameters that can be beneficial for COVID-19 patients. It can be concluded that LDRT might offer a possible treatment protocol for COVID-19 patients with the Alzheimer's gene who need hospitalization and intensive care.

Keywords: Low Dose X-Ray Radiation (LDXR); Alzheimer's disease; COVID-19; SARS-CoV-2; Coronavirus

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