alexa Mesenchymal Stem Cell Applications for Ligament Repair
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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Review Article

Mesenchymal Stem Cell Applications for Ligament Repair after Joint Trauma

Dimitrios Kouroupis1*, Sarah M. Churchman2, Peter V. Giannoudis3, and Elena Jones2

1Department of Biomedical Research, Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, University Campus of Ioannina, Ioannina, Greece

2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

3University of Leeds, School of Medicine, Academic Department of Trauma and Orthopaedics, Leeds, United Kingdom

*Corresponding Author:
Dimitrios Kouroupis, PhD
Department of Biomedical Research
Foundation for Research and Technology-Hellas
Institute of Molecular Biology and Biotechnology
University Campus of Ioannina, Ioannina, Greece
Tel: +302651007816
E-mail: [email protected]

Received Date: July 23, 2014; Accepted Date: August 19, 2014; Published Date: August 21, 2014

Citation: Kouroupis D, Churchman SM, Giannoudis PV, Jones E (2014) Mesenchymal Stem Cell Applications for Ligament Repair after Joint Trauma. J Clin Exp Pathol 4:186. doi: 10.4172/2161-0681.1000186

Copyright: © 2014 Kouroupis sD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Tendon and ligament injuries are the most common problems in adult health accounting for about half of all musculoskeletal injuries. Rupture of the anterior cruciate ligament (ACL) results in the loss of whole joint stability leading to meniscal rupture, cartilage damage and early osteoarthritis. Arthroscopic reconstruction using autografts or allografts has known drawbacks such as ligament laxity, donor site morbidity and long recovery periods. In addition to the appropriate mechanical environment, several biological factors have been implicated in the ACL healing process including specialised growth factors and mesenchymal stem cells (MSCs). However, in order to produce a superior molecular and biomechanical ACL there will be always the need to provide a suitable scaffold to ‘house’ MSCs and to provide adequate biomechanical properties in order for the regeneration process to proceed. Understanding the mechanisms of ACL healing following cellular therapy may lead to novel, more effective and biological-based tissue engineering strategies for ACL reconstruction. The focus of this review is the current knowledge of ACL reconstruction after joint trauma when combining MSC and tissue engineering technologies.


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