Abstract

This compilation of systematic reviews and meta-analyses highlights critical advancements and ongoing challenges in endodontics. It covers improved irrigation techniques for smear layer and biofilm disruption, the development of biocompatible root canal sealers, and the success of regenerative procedures for immature teeth. Diagnostic precision is enhanced by Cone-beam Computed Tomography (CBCT), revealing higher prevalence of apical periodontitis than traditional radiography. Challenges remain in complete smear layer removal, retreatment efficacy, and individualized pain management, underscoring the continuous evolution of materials, techniques, and diagnostic tools for optimal patient outcomes.