Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in FibrosisKonstantinos Ritis* and Konstantinos Kambas
Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece
- *Corresponding Author:
- Ritis K, MD, PhD
University Hospital of Alexandroupolis
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Received date: May 14, 2015 Accepted date: July 08, 2015 Published date: July 12, 2015
Citation: Ritis K, Kambas K (2015) Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in Fibrosis. J Clin Exp Pathol 5:239. doi: 10.4172/2161-0681.1000239
Copyright: ©2015 Ritis K, et al. This is an open-access article` distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fibrosis is a dynamic process of abnormal connective tissue formation as a result of excessive wound healing and extracellular matrix deposition. It can occur in almost all tissues and it is a major contributor to clinical diseases, leading to organ failure and accounting for approximately one third of deaths worldwide [1,2]. It is proposed that fibrotic response may be distinguished in four major phases: 1) the initiation after tissue injury; 2) the activation of effector cells; 3) the deposition of extracellular matrix and 4) the progression to fibrosis with subsequent organ failure by excessive accumulation of extracellular matrix without sufficient degradation .