alexa Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in Fibrosis
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Short Communication

Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in Fibrosis

Konstantinos Ritis* and Konstantinos Kambas

Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece

*Corresponding Author:
Ritis K, MD, PhD
University Hospital of Alexandroupolis
Dragana, Alexandroupolis
GREECE
Fax: 30 25510 30378
Tel: 30 25513 51103
Email:
[email protected]

Received date: May 14, 2015 Accepted date: July 08, 2015 Published date: July 12, 2015

Citation: Ritis K, Kambas K (2015) Neutrophil Extracellular Traps - The Invisible Inflammatory Mediator in Fibrosis. J Clin Exp Pathol 5:239. doi: 10.4172/2161-0681.1000239

Copyright: ©2015 Ritis K, et al. This is an open-access article` distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Fibrosis is a dynamic process of abnormal connective tissue formation as a result of excessive wound healing and extracellular matrix deposition. It can occur in almost all tissues and it is a major contributor to clinical diseases, leading to organ failure and accounting for approximately one third of deaths worldwide [1,2]. It is proposed that fibrotic response may be distinguished in four major phases: 1) the initiation after tissue injury; 2) the activation of effector cells; 3) the deposition of extracellular matrix and 4) the progression to fibrosis with subsequent organ failure by excessive accumulation of extracellular matrix without sufficient degradation [2].

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