Abstract

Next-generation sequencing (NGS) has revolutionized the field of cancer genomics, providing unprecedented insights into the genetic landscape of tumors. This technology allows for comprehensive analysis of genomic alterations, enabling the identification of biomarkers that can guide diagnosis, treatment decisions, and prognostic evaluations. This article reviews the methodologies and applications of NGS in cancer genomics, highlighting its role in personalized medicine and the development of targeted therapies. We discuss the clinical implications of NGS, including its impact on early detection, treatment response, and monitoring disease progression. Additionally, we address the challenges and future directions of NGS in the context of cancer research and clinical practice. Ultimately, NGS represents a paradigm shift in cancer diagnosis and treatment, facilitating more effective and individualized patient care.