alexa Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations

Mohamed A El Hamd1, Ramadan Ali1 and Ahmed A H Abdellatif2*

1Department of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

*Corresponding Author:
Ahmed A. H. Abdellatif
Department of Pharmaceutics and Industrial Pharmacy
Faculty of Pharmacy, Al-Azhar University
Assuit 71524, Egypt
Tel: +201016660069
E-mail: [email protected]

Received Date: December 11, 2015; Accepted Date: December 28, 2015; Published Date: January 26, 2016

Citation: Hamd MAE, Ali R, Abdellatif AAH (2016) Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations. J Anal Bioanal Tech 7:294. doi: 10.4172/2155-9872.1000294

Copyright: © 2016 Hamd MAE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Non-aqueous titrations is the most titrimetric procedure used in pharmacopoeial assays and serves a double purpose, as it suitable for the titration of weak acids and bases and provides a solvent in which organic compounds are soluble. A simple, cost-effective, rapid, and precise method for determination of loratadine (LOR) in pure and pharmaceutical dosage forms was developed. The method based on non-aqueous titration using acetous perchloric acid as a titrant and acetous crystal violet as indicator. All measurements are carried out by running simultaneous blank determinations and the final titer values are subtracted from blank to get actual amount of acetous perchloric acid equivalent to LOR. The method was successfully applied for determination of LOR in pure and some pharmaceutical preparations. The percentage recoveries of the proposed method were ranged from 84.8 ± 0.1% to 100.9 ± 0.1%. The method showed an acceptable precision and accuracy as it able to determine LOR in presence of the different excipients present in some commercial preparations without any significant interference.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords