Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations
- *Corresponding Author:
- Ahmed A. H. Abdellatif
Department of Pharmaceutics and Industrial Pharmacy
Faculty of Pharmacy, Al-Azhar University
Assuit 71524, Egypt
E-mail: [email protected]
Received Date: December 11, 2015; Accepted Date: December 28, 2015; Published Date: January 26, 2016
Citation: Hamd MAE, Ali R, Abdellatif AAH (2016) Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations. J Anal Bioanal Tech 7:294. doi: 10.4172/2155-9872.1000294
Copyright: © 2016 Hamd MAE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Non-aqueous titrations is the most titrimetric procedure used in pharmacopoeial assays and serves a double purpose, as it suitable for the titration of weak acids and bases and provides a solvent in which organic compounds are soluble. A simple, cost-effective, rapid, and precise method for determination of loratadine (LOR) in pure and pharmaceutical dosage forms was developed. The method based on non-aqueous titration using acetous perchloric acid as a titrant and acetous crystal violet as indicator. All measurements are carried out by running simultaneous blank determinations and the final titer values are subtracted from blank to get actual amount of acetous perchloric acid equivalent to LOR. The method was successfully applied for determination of LOR in pure and some pharmaceutical preparations. The percentage recoveries of the proposed method were ranged from 84.8 ± 0.1% to 100.9 ± 0.1%. The method showed an acceptable precision and accuracy as it able to determine LOR in presence of the different excipients present in some commercial preparations without any significant interference.