Abstract

This compilation highlights significant advances in non-opioid strategies for chronic and neuropathic pain management. Research focuses on diverse therapeutic targets, including peripheral glial cells, voltage-gated sodium channels (VGSCs), the endocannabinoid system, P2X7 receptors, TRPA1 channels, and G protein-coupled receptors (GPCRs). Emerging non-viral gene therapy also shows promise. These efforts aim to develop safer, more effective pain relief options, moving beyond traditional neuronal targets to address the limitations of existing treatments and mitigate the opioid crisis with novel pharmacological agents and mechanisms. This broad approach underscores a concerted effort towards innovative pain management solutions.