ISSN 2472-016X

Journal of Orthopedic Oncology
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  • Research Article   
  • J Orthop Oncol 2019, Vol 5(1): 130
  • DOI: 10.4172/2472-016X.1000130

Overview of Bone Tumours in a Tertiary Care Hospital

Jeyaraman M1*, Ramesh R1, Chaudhari K1, Ajay SS1, Mendiratta D1, Likhith D1, Sushmita H2, Nilekani A2, Aradhyula K3 and Selvaraj P4
1Department of Orthopaedics, JJM Medical College, Davangere, Karnataka, India
2Department of Pathology, JJM Medical College, Davangere, Karnataka, India
3Department of Radio Diagnosis, JJM Medical College, Davangere, Karnataka, India
4Department of Community Medicine, SRM Medical College, Chennai, Tamil Nadu, India
*Corresponding Author : Jeyaraman M, Junior Resident, Department of Orthopedics, JJM Medical College, Davangere, Karnataka, India, Tel: 8310600785, Email: madhanjeyaraman@gmail.com

Received Date: Apr 15, 2019 / Accepted Date: May 13, 2019 / Published Date: May 20, 2019

Abstract

Background: The neoplasms of bone account for only 0.2%–0.5% of the overall human tumour biology. Most bone tumours arise de-novo from genetic mutations; but numerous risk factors such as chemotherapy, irradiation, foreign bodies, bone infarcts and pre-existing bone lesions have been implicated. Bone tumours have heterogeneous population of cells and morphology. For accurate diagnosis of tumours and tumour like lesions of bone, there is a need of tissue diagnosis & staging and radiological diagnosis to delineate the plane of tumour involvement and its appropriate management.
Objectives: To study the spectrum of clinico-radiological & histopathological features and management of tumour and tumour like lesions of bone and to establish the statistical significance by testing the agreement between clinicoradiological and histopathological diagnosis by Cohen’s kappa value.
Materials and Methods: A total of 76 cases (14 clinical entities) were taken in our study. All cases underwent thorough clinical, hematological and radiological investigations to arrive at an empirical diagnosis of the lesions. Then all patients were subjected for histopathological tissue sampling (FNAB (Fine Needle Aspiration Biopsy) or incisional biopsy) for accurate diagnosis which guide the orthopaedic surgeon to plan the appropriate line of management. All the cases were under surveillance for diagnosing the development of metastasis.
Results: The histopathological correlation of 95.37% with 97.25% sensitivity, 95.41% specificity, 97.01% positive predictive value and 95.41% negative predictive value in diagnosing musculoskeletal tumours. The strength of agreement between clinico-radiological and histopathological diagnosis by Cohen’s kappa value was very good (κ=0.817).
Conclusion: The management of tumours and tumour like lesions of bone pose a greater challenge for an orthopaedic surgeon in instituting treatment modalities. The successful diagnosis of bone tumour and its management depends on collaboration between the orthopaedic surgeon and the pathologist who determine the need for secondary biopsy in diagnosing bone and soft tissue tumourse.

Keywords: Bone Tumours; Cohen’s Kappa; Histopathology; Fine Needle Aspiration Biopsy (FNAB); Incisional Biopsy

Citation: Jeyaraman M, Ramesh R, Chaudhari K, Ajay SS, Mendiratta D, et al. (2019) Overview of Bone Tumours in a Tertiary Care Hospital. J Orthop Oncol 5: 130. Doi: 10.4172/2472-016X.1000130

Copyright: © 2019 Jeyaraman M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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