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Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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  • Research Article   
  • J Clin Exp Pathol 2014, Vol 4(1): 152
  • DOI: 10.4172/2161-0681.1000152

Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report

Jing Liu1*, Robert E Brown1, Sheldon Rubenfeld2 and Ron J Karni3
1of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA
2Department of Internal Medicine, Baylor College of Medicine and University of Texas School of Nursing at Houston, Houston, Texas, USA
3Department of Otorhinolaryngology – Head & Neck Surgery, University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA
*Corresponding Author : Jing Liu, Department of Pathology and Laboratory Medicine, University Of Texas Health Science Center At Houston Medical School, 6431 Fannin Street, MSB 2.260A, Houston, Texas, USA, Tel: 713 500 5327, Fax: 713 500 0695, Email: [email protected]

Received Date: Oct 23, 2013 / Accepted Date: Nov 28, 2013 / Published Date: Dec 02, 2013

Abstract

Papillary Thyroid Carcinoma (PTC) with prominent hobnail features is a recently recognized aggressive variant of PTC. The cytologic features and molecular characterization have not been fully investigated. We present a patient with a preoperative fine needle aspiration diagnosis of PTC with hobnail features that demonstrated constitutive activation of mTOR pathway with evidence of mTORC2 activation on immunohistochemical staining. These findings may be of value for clinical management, targeted therapy, and prognostication.

Keywords: Cytopathology, Fine needle aspiration, Hobnail variant, Immunohistochemistry, mTOR, Papillary thyroid carcinoma

Citation: Liu J, Brown RE, Rubenfeld S, Karni RJ (2013) Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report. J Clin Exp Pathol 4:152. Doi: 10.4172/2161-0681.1000152

Copyright: © 2013 Liu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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