Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case ReportJing Liu1*, Robert E Brown1, Sheldon Rubenfeld2 and Ron J Karni3
- *Corresponding Author:
- Jing Liu
Department of Pathology and Laboratory Medicine
University of Texas Health Science Center at Houston Medical School
6431 Fannin Street, MSB 2.260A, Houston, Texas, USA
Tel: 713 500 5327
Fax: 713 500 0695
E-mail: [email protected]
Received date: October 23, 2013; Accepted date: November 28, 2013; Published date: December 02, 2013
Citation: Liu J, Brown RE, Rubenfeld S, Karni RJ (2013) Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report. J Clin Exp Pathol 4:152. doi:10.4172/2161-0681.1000152
Copyright: © 2013 Liu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Papillary Thyroid Carcinoma (PTC) with prominent hobnail features is a recently recognized aggressive variant of PTC. The cytologic features and molecular characterization have not been fully investigated. We present a patient with a preoperative fine needle aspiration diagnosis of PTC with hobnail features that demonstrated constitutive activation of mTOR pathway with evidence of mTORC2 activation on immunohistochemical staining. These findings may be of value for clinical management, targeted therapy, and prognostication.