ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Mini Review   
  • J Infect Dis Ther 2017, Vol 6(1): 353
  • DOI: 10.4172/2332-0877.1000353

Clinical Differences in Hospitalized Adult Influenza Patients between the A (H1N1) pdm09 and the A (H3N2) Seasons in Japan

Nozomi Oikawa1,2 and Masafumi Seki1*
1Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, , Japan
2Laboratory for Clinical Microbiology, Tohoku Medical and Pharmaceutical University Hospital, , Sendai City, Miyagi, Japan
*Corresponding Author : Masafumi Seki, Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai City, Miyagi 983-8612, Japan, Tel: +81-22-983-1221, Fax: +81-22-983-0507, Email: seki@hosp.tohoku-mpu.ac.jp

Received Date: Jan 30, 2018 / Accepted Date: Feb 19, 2018 / Published Date: Feb 22, 2018

Abstract

To determine the differences in the clinical features of hospitalized elderly patients with influenza between the A (H1N1) pdm09 and the A (H3N2)-dominant seasons, 12 adult patients (mean age, 76.5 years) with influenza who were hospitalized during the 2015-2016 A (H1N1) pdm09-dominant season were compared with 26 adult patients (mean age, 82.5 years) with influenza who were hospitalized during the 2016-2017 A (H3N2)-dominant season. Compared with the A (H3N2)-dominant 2016-2017 season, the A (H1N1) pdm09-dominant 2015-2016 season had fewer non-survivors, but had significantly fewer patients who required oxygenation/respirator support and intravenous anti-influenza agents, such as peramivir. Among the severe patients who received oxygenation/respirator support, the outcomes were better in the A (H3N2)-dominant 2016-2017 season than in the A (H1N1) pdm09-dominant 2015-2016 season. The pneumonia types and detected bacteria did not differ between the two seasons, but the use of sulbactam/ampicillin was more frequent in the A (H1N1) pdm09-dominant 2015-2016 season than in the A (H3N2)-dominant 2016-2017 season. These data suggest that peramivir treatment and oxygenation/respirator support, but not sulbactam/ampicillin administration, may improve the outcome of severe elderly patients hospitalized for influenza, especially the A (H3N2) type.

Keywords: Influenza; Pneumonia; Peramivir; Oxygenation; Respirator; Sulbactam/ampicillin

Citation: Oikawa N, Seki M (2018) Clinical Differences in Hospitalized Adult Influenza Patients between the A (H1N1) pdm09 and the A (H3N2) Seasons in Japan. J Infect Dis Ther 6: 353. Doi: 10.4172/2332-0877.1000353

Copyright: © 2018 Oikawa N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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