alexa Effect of Gamma Ray on Reactive Oxygen Species at Experimental Animals | OMICS International| Abstract

ISSN:2167-7964

OMICS Journal of Radiology

  • Research Article   
  • OMICS J Radiol 2017, Vol 6(6): 283
  • DOI: 10.4172/2167-7964.1000283

Effect of Gamma Ray on Reactive Oxygen Species at Experimental Animals

Zakaria KM*
Nuclear and Radiological Regulatory Authority, , Egypt
*Corresponding Author : Zakaria KM, Nuclear and Radiological Regulatory Authority, Nasr City 11762, P. O. Box: 7551, Cairo, Egypt, Email: [email protected]

Received Date: Nov 06, 2017 / Accepted Date: Nov 30, 2017 / Published Date: Dec 06, 2017

Abstract

The present study was designed to investigate the oxidative stress, which is due to the effect of low doses of gamma irradiation. Animals were divided into 6 groups, where the first group kept as control group, while 2nd, 3rd, 4th, 5th and 6th groups were exposed to gamma ray at 1.5 Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy once weekly for one month respectively. Rats were subjected to gamma radiation and nitric oxides (NO), superoxide dismutase (SOD), malondialdehyde, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and white blood cells (WBCs) were measured. SOD recorded highly significant decrease with percent change -22.7%, -25.01%, -55.01% -55.4% and -56.38% respectively in groups which were exposed to 1.5, 2, 2.5, 3 and 3.5 Gy. MDA serum level have a significant increase in groups which were exposed to successive doses of 1.5 Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively with percent change 25.7% , 41.8% 59.1% 65.6% 75.8% consequently as compared to control group. Nitric oxide serum level is markedly showed highly significant increase in rats exposed to successive dose of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively with percent change 59.69%, 74.17%, 87.1%, 120.1% and 130.6% consequently as compared to control group. ALT and AST recorded highly significant increase in rats exposure to successive doses of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively. On the other hand WBCs recorded highly significant decreased in rats exposed to successive dose of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively. WBCs recorded percent change -26.11%, -32.3%, -47.8%, -50.1% and -53.6% respectively as compared to control group.

Keywords: Reactive oxygen species; Nitric oxides; Superoxide dismutase; Gamma ray; Malondialdehyde

Citation: Zakaria KM (2017) Effect of Gamma Ray on Reactive Oxygen Species at Experimental Animals. OMICS J Radiol 6: 283. Doi: 10.4172/2167-7964.1000283

Copyright: ©2017 Zakaria KM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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