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Journal of Clinical & Experimental Pathology
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  • Case Report   
  • J Clin Exp Pathol 2014, Vol 4(2): 160
  • DOI: 10.4172/2161-0681.1000160

Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology

Janati A1, AL Ghasab Naif S2*, Sofiane Ghorbel3, Budoor A. Al-Emadi4, Kareemah S. Al-Shurtan2, Abdulmohsen S. Alghassab5, Lila S. Seada6, Muhammad Umair7, Nour M Alfahhad8 and Hani Al Shubaili9
1Division of Neurology, Neurology Center of Fairfax, Virginia, USA
2Hail University, Hail, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
3Center of Rehabilitation, King Khaled Hospital, Hail, Saudi Arabia
4Department of Medicine, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
5Medical school at Hail University, Hail, KSA
6Department of Pathology, King Khaled Hospital, Hail, Saudi Arabia
7Department of Medicine, Dow Medical College, Karachi, Pakistan
8Qassim University, Saudi Arabia
9Dean of Qassim medical school, Division of Dermatology, Qassim University, Saudi Arabia
*Corresponding Author : AL Ghasab Naif S, Hail University, Hail, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, Tel: 00966507886878, Email: [email protected]

Received Date: Jan 15, 2014 / Accepted Date: Feb 11, 2014 / Published Date: Feb 13, 2014

Abstract

Introduction: Isotretinoin is the mainstay therapy for severe and nodulocystic acne. Myalgia and muscle stiffness have been reported in 16-51% of patients treated with isotretinoin, while elevated serum Creatine Kinase (CK) levels have been found in up to 41%. In this paper, we report, for the first time, the occurrence of myopathy limited to the pelvic-girdle muscles in a teen who received isotretinoin therapy.
Methods: This was a case study conducted at King Khalid Hospital.
Results: Histopathology and other laboratory data were consistent with an inflammatory myopathy based on a vasculitic process.
Conclusion: Our data indicate that the myopathy caused by isotretinoin is an inflammatory process based on vasculitis, resulting in ischemic muscle necrosis.

Citation: Janati A, Naif AG, Ghorbel S, Al-Emadi BA, Al-Shurtan KS, et al. (2014) Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology. J Clin Exp Pathol 4:160. Doi: 10.4172/2161-0681.1000160

Copyright: © 2014 Ghorbel S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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