Abstract

This collection of reviews offers a comprehensive look at modern pain management strategies, emphasizing multimodal and personalized approaches. It covers perioperative pain in patients with chronic pain and opioid tolerance, advocating for opioidsparing techniques and non-opioid analgesics. The data explores advancements in ultrasound-guided regional anesthesia and the development of novel pharmacological targets for postoperative pain. Considerations for opioid-free anesthesia, pediatric pain, chronic non-cancer pain, and acute pain in emergency settings are also highlighted. The overarching theme points towards reducing opioid reliance through diverse interventions and understanding molecular mechanisms for targeted, safer pain relief.