Abstract

Intracellular deposits of aggregated α synuclein, ubiquitin, and other proteins found in many surviving neuronal populations are considered to be the pathologic characteristic of Parkinsons Disease. Whether Lewy bodies are themselves neurotoxic, or represent the end product of cellular defence mechanisms to sequester toxic abnormal proteins, remains to be determined.

Keywords: Causal mutations; Dominant early-onset; Leucine-rich; Non-familial disease; Response rates; Exercise prescription