alexa Prediction of Adverse Radiotherapeutic Effects in Prostate Cancer Patients Prior to Radiation
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Prediction of Adverse Radiotherapeutic Effects in Prostate Cancer Patients Prior to Radiation

Yusheng Zhu1* and David T. Marshall2

1Departments of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA

2Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA

*Corresponding Author:
Yusheng Zhu
Department of Pathology and Laboratory Medicine
Medical University of South Carolina, 171 Ashley Avenue
MSC 908, Suite 309, Charleston, SC 29425, USA
Tel: +1 (843)792-8814
Fax: +1 (843)792-0424
E-mail: [email protected]

Received date: August 29, 2012; Accepted date: August 30, 2012; Published date: September 03, 2012

Citation: Zhu Y, Marshall DT (2012) Prediction of Adverse Radiotherapeutic Effects in Prostate Cancer Patients Prior to Radiation. J Clin Exp Pathol 2:e112. doi: 10.4172/2161-0681.1000e112

Copyright: © 2012 Zhu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



It is estimated that there will be 241,740 new Prostate Cancer (PCa)
cases diagnosed in the U.S. in 2012 [1]. Radiotherapy is a widely used
treatment modality for PCa. A recent review revealed that approximately
48% of patients diagnosed with prostate cancer received some form of
radiotherapy for their initial treatment [2]. This amounts to around
100,000 patients per year receiving radiotherapy for PCa in the United
States alone with a risk of grade 2 or higher bladder or gastrointestinal
toxicity of 7-38% [3-5]. This adds up to 7,000 to 38,000 moderate or
worse toxicities and up to 2000 severe toxicities each year. Indeed, most
PCa patients have mild to moderate side-effects from radiotherapy, but
some patients do have severe Adverse Radiotherapeutic Effects (AREs),
such as severe lower urinary tract irritation, erectile dysfunction,
and rectal bleeding, ulceration or dysfunction, despite the fact that
radiotherapy doses and techniques are generally uniform. These severe
side effects cause significant morbidity and require costly intervention.

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