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Prevalence of Chromosome 8 Aneuploidy in Egyptian Acute Myeloid Leukemia Patients using Fluorescence in situ Hybridization | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2016, Vol 6(5): 297
  • DOI: 10.4172/2161-0681.1000297

Prevalence of Chromosome 8 Aneuploidy in Egyptian Acute Myeloid Leukemia Patients using Fluorescence in situ Hybridization

Eyada TM1, Botros SK1*, El Noshokaty EH2 and Nabil G2
1Department of Clinical Pathology, Kasr El Ainy Medical School, Cairo, Egypt
2Department of Clinical pathology, National Cancer Institute, Cairo, Egypt
*Corresponding Author : Botros SK, 26 Atbara St from Amed Oraby, Agouza, Giza, Egypt, Tel: +201223780160, Email: [email protected]

Received Date: Sep 07, 2016 / Accepted Date: Oct 21, 2016 / Published Date: Oct 24, 2016

Abstract

Trisomy 8 is one of the commonest recurring aberrations in myeloid hematologic malignancies. This study aimed to detect the prevalence of chromosome 8 aneuploidy in Egyptian AML patients and analyse its prognostic impact. Forty newly diagnosed AML patients were studied. Karyotyping was performed and the presence of chromosome 8 aneuploidy was tested with the FISH technique. Trisomy 8 was detected in 2 cases (5%) of de novo AML patients as a sole anomaly, monosomy 8 in 1 case (2.5%), t(8;21) in 3 cases (7.5%) and t(15;17) in one case (2.5%). Association between chromosome 8 aneuploidy and other laboratory variables could not be assessed owing to the small number of patients showing this aberration. Conclusion: This study provided the opportunity to investigate the incidence of chromosomale 8 aneuploidy in Egyptian AML patients. Further studies using larger sam

Keywords: Myeloid leukemia; Aneuploidy; Trisomy 8; Malignancy; Cytogenetics; Prognosis; Chromosomal abnormalities; Karyotype; Aberration; Aneuploidy

Citation: Eyada TM, Botros SK, El Noshokaty EH, Nabil G (2016) Prevalence of Chromosome 8 Aneuploidy in Egyptian Acute Myeloid Leukemia Patients using Fluorescence in situ Hybridization. J Clin Exp Pathol 6:297. Doi: 10.4172/2161-0681.1000297

Copyright: © 2016 Eyada TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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