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Prognostic and Predictive Value of Lymphoid Microenvironment in Locally Advanced Rectal Cancer | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • Research Article   
  • J onco res treat,

Prognostic and Predictive Value of Lymphoid Microenvironment in Locally Advanced Rectal Cancer

Ihsane El Otmani1,2,3*, Fatima El Agy1,2, Nada Lahmidani4, Mohammed El Abkari4, Dafr-Allah Benajah4, Imane Toughrai5, Hicham El Bouhaddouti5, Ouadii Mouaquit5, Karim Ibn Majdoub Hassani5, Khalid Mazaz5, El Bachir Benjelloun5, Abdelmalek Ousadden5, Touria Bouhafa6, Zineb Benbrahim7, Sidi Adil Ibrahimi5, Khalid Ait Taleb5 and Laila Chbani1,2
1 Department of Medical Genetics and Oncogenetics, Laboratory of Biomedical and Translational Research, Sidi Mohamed Ben Abdellah University, Fez, Morocco
2Department of Medical Genetics and Oncogenetics, Laboratory of Anatomic Pathology and Molecular Pathology, Hassan II University Hospital, Mohamed Ben Abdellah University, Fez, Morocco
3Department of Medical Genetics and Oncogenetics, Hassan II University Hospital, Sidi Mohamed Ben Abdullah University, Fez, Morocco
4Department of Gastroenterology, Hassan II University Hospital, Sidi Mohamed Ben Abdullah University, Fez, Morocco
5Department of Epidemiology, Hassan II University Hospital, Sidi Mohamed Ben Abdullah University, Fez, Morocco
6Department of Radiotherapy, Hassan II University Hospital, Sidi Mohamed Ben Abdullah University, Fez, Morocco
7Department of Oncology, Hassan II University Hospital,Sidi Mohamed Ben Abdullah University, Fez, Morocco
*Corresponding Author : Ihsane El Otmani, Department of Medical Genetics and Oncogenetics, Laboratory of Anatomic Pathology and Molecular Pathology, Hassan II University Hospital,Mohamed Ben Abdellah University, Fez, Morocco, Tel: +212669025449, +2120700116013, Email: [email protected]

Received Date: Oct 08, 2021 / Accepted Date: Oct 22, 2021 / Published Date: Oct 29, 2021

Abstract

Objective: Tumor immunity infiltrate, density and location in the microenvironment could be predictive value for survival in patients with rectal cancer. The aims of this study is to evaluate tumor microenvironment using immune adaptive cells as CD3+ and CD8+ T lymphocytes and explore relationship between clinic pathological features, therapeutic response, survival outcomes and immunoscore.

Materials and Methods: Scoring system “immunoscore” in pretreated biopsies tissues from rectal cancer. Quantification of cytotoxic and memory T cells in the Core of Tumor (CT) and in the tumor’s Invasive Margin (IM)

Results: According to 5 immunoscore groups I0, I1, I2, I3 and I4, the frequency of each group was respectively 9.3%, 18.5%, 22.2%, 18.5% and 31.5%. When grouping immunoscore into 3 groups’ data allow to a proportion of 27.8% for low immunoscore, 22.2% for moderate immunoscore and 50% for high immunoscore. Furthermore, in two-tailed classification (I0, I1, I2 versus I3 and I4) 50% of tumors were ranged as low immunoscore versus 50% as high immunoscore.

Conclusion: High Lymphoid infiltration in CT and IM prove that tumor microenvironment could be a predictive factor, on pretreated biopsies, for tumor sensibility after neoadjuvant treatment in rectal cancer. This reflects the importance role of high immune infiltration in prediction of complete therapeutic effect. Immunoscore method should be considered as predictive marker for overall survival.

Keywords: Immunoscore, CD3, CD8, Therapeutic response, Rectal cancer, Neoadjuvant treatment, Morocco.

Citation: Otmani IE, Agy FE, Lahmidani N, Abkari ME, Benajah DA, et al. (2021) Prognostic and Predictive Value of Lymphoid Microenvironment in Locally Advanced Rectal Cancer. J Oncol Res Treat S5: 003.

Copyright: © 2021 Otmani IE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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