alexa

GET THE APP

Prognostic Value of the Expression of Endogenous Hypoxia Associated Proteins Hypoxia Inducible Factor-1 Alpha (HIF-1and#945;) and Carbonic Anhydrase Isoform 9 (CAIX) Expressions in Breast Carcinoma| Abstract

Journal of Oncology Research and Treatment
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Oncol Res Treat 2017. 2:1,

Prognostic Value of the Expression of Endogenous Hypoxia Associated Proteins Hypoxia Inducible Factor-1 Alpha (HIF-1α) and Carbonic Anhydrase Isoform 9 (CAIX) Expressions in Breast Carcinoma

Ola Abdelraouf Harb1*, Ibtesam E2, Amal MAA2, Warda MS2, Sharifa A2, Basant S3, Loay MG4 and Osama AE4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya
3Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazi, Egypt
*Corresponding Author : Ola Abdelraouf Harb, Faculty of Medicine, Department of Pathology, Zagazig University, 44519, Egypt, Tel: 01224963123, Email: [email protected]

Received Date: Oct 20, 2017 / Accepted Date: Nov 28, 2017 / Published Date: Dec 04, 2017

Abstract

Background: Hypoxia has been found to be related to malignant initiation, progression, increasing the occurrence of metastasis and therapy resistance in many cancer types, which made a real need for discovering drugs that could antagonize the bad effect of hypoxia in cancer, decide which patients will have benefit from such anti-hypoxia therapy then to monitor response to therapy, especially in breast carcinoma.
It is important to detect degree of hypoxia in each cancer that could be done by evaluation of the expression of hypoxia-associated proteins in cancer biopsies e.g. hypoxia inducible factor-1 alpha (HIF-1α) and carbonic anhydrase IX (CAIX) and their detailed role in breast cancer is still uncertain and gives conflicting results.
Aim of the work: Aim of the work was to evaluate HIF-1α and CAIX expressions in breast carcinoma, correlating their expressions with each other, with presence of lymph node and distant metastases, with recurrence free and overall survival rates of female patients with breast cancer.
Methods: We evaluated HIF-1α and CAIX expressions in sections from 90 paraffin blocks of breast carcinoma using immunohistochemistry. We analyzed correlations between their levels of expressions, clinic-pathological and prognostic parameters of our patients.
Results: HIF-1α and CAIX positive expression in breast carcinoma was related to advanced stage, presence of lymph node metastases, HER2 amplified and triple negative molecular subtypes (p<0.001), higher tumor grade (p=0.001 and 0.02 respectively) and negative ER (p=0.005 and 0.008 respectively) and PR (p=0.009 and 0.027 respectively) hormonal receptors, The expression of both markers was significantly positively correlated with each other (p<0.001). HIF-1α and CAIX positive expression in breast carcinoma was associated with shortened recurrence free and overall survival rates (p<0.001).
Conclusion: HIF-1α and CAIX are markers of poor prognosis of breast carcinoma patients.

Keywords: Breast carcinoma; Hypoxia; HIF-1α; CAIX; Immunohistochemistry; Prognosis

Citation: Harb OA, Ibtesam E, Amal MAA, Warda MS, Sharifa A, et al. (2017) Prognostic Value of the Expression of Endogenous Hypoxia Associated Proteins Hypoxia Inducible Factor-1 Alpha (HIF-1α) and Carbonic Anhydrase Isoform 9 (CAIX) Expressions in Breast Carcinoma. J Oncol Res Treat 2: 116.

Copyright: © 2017 Harb OA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 2466
  • [From(publication date): 0-2017 - Nov 30, 2021]
  • Breakdown by view type
  • HTML page views: 2160
  • PDF downloads: 306
Top