alexa Prolactin, Thyroid Stimulating Hormone and Thyroid Hormones (Ft3, Ft4) Concentrations in Female Patients with Inferility: An Observational Study | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2017, Vol 7(6): 327
  • DOI: 10.4172/2161-0681.1000327

Prolactin, Thyroid Stimulating Hormone and Thyroid Hormones (Ft3, Ft4) Concentrations in Female Patients with Inferility: An Observational Study

Madeeha Subhan1*, Waleed Sadiq2 and Sanniyah Subhan3
1Capital Hospital, , Islamabad, 44000, Pakistan
2Shifa International Hospital, , Islamabad, 44000, Pakistan
3Quaid-i-Azam University, Islamabad, 44000, Pakistan
*Corresponding Author : Madeeha Subhan, Capital Hospital, Islamabad, 44000, Pakistan, Tel: 00923335634888, Email: [email protected]

Received Date: Aug 31, 2017 / Accepted Date: Nov 24, 2017 / Published Date: Nov 28, 2017

Abstract

Objective: To determine the variations in thyroid hormones, thyroid stimulating hormone and prolactin levels in females of our population.

Materials and methods:

Subject characteristics: Patients aged 13 to 60 years were studied for their hormonal profile. The inclusion criteria had patients with complaints of mild reproductive and thyroid dysfunction. Patients with severe disorders and cancerous conditions were excluded from the study.

Blood sampling: 3 ml blood was drawn and transferred to clean test tubes. Blood was centrifuged at 3000 rpm for 10-15 min. Serum was separated and stored at -20°C.

Hormonal assay: Thyroid stimulating hormone (TSH), Prolactin, FT3 and FT4 were assayed in the serum. Equipment used in laboratory was Eclecsys 2010 (Roche). Principle of the hormonal test was based on ECL (Electrochemiluminescence). Standard kits by Roche were used for chemical analysis. The results were analyzed by using ANOVA in SPSS (version 10.0 for windows).

Results: A total of 97 patients were tested. The patients were divided into four major groups, showed overall nonsignificant variation in hormonal level for Prolactin, FT3 and FT4 (p>0.05). About 80% patients were found normal, in TSH estimation. Women from age 16-35 years old were greater in number than any other age group. Means for each hormone were non-significant at p=0.05.

Conclusion: Hyperprolactinemia causes reproductive disorders in women, early diagnosis and treatment of this disease is important. In conclusion estimation of prolactin and TSH levels might be considered essential in assessment of patient with fertility disorders.

Keywords: FT3; FT4; TSH; Prolactin; Endocrine hormone

Citation: Subhan M, Sadiq W, Subhan S (2017) Prolactin, Thyroid Stimulating Hormone and Thyroid Hormones (Ft3, Ft4) Concentrations in Female Patients with Inferility: An Observational Study. J Clin Exp Pathol 7: 327. Doi: 10.4172/2161-0681.1000327

Copyright: ©2017 Subhan M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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