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ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Review Article

Recent Advances towards Understanding the Role of Opioid Receptor Phosphorylation

Daccache G and Allouche S*

Normandy University, Caen, France; UNICAEN EA 4650 Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, UFR de Médecine, Université de Caen, Caen Cedex 5, CS14032 CAEN, France

*Corresponding Author:
Allouche S
Laboratoire de Biochimie, Centre Hospitalier et Universitaire
Avenue Côte de Nacre, CS 300001, 14033 Caen cedex 9, France
Tel: +33 231065419
Fax: +33 231065172
E-mail: [email protected]

Received date: December 29, 2015; Accepted date: January 27, 2016; Published date: January 30, 2016

Citation: Daccache G, Allouche S (2016) Recent Advances towards Understanding the Role of Opioid Receptor Phosphorylation . J Clin Exp Pathol 6:264. doi:10.4172/2161-0681.1000264

Copyright: © 2016, Daccache G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 

Opioid receptors, including mu (MOR for mu-opioid receptor), delta (DOR for delta-opioid receptor) and kappa (KOR for kappaopioid receptor), belong to the super family of G-protein coupled receptors (GPCRs). Those receptors, and particularly the MOR, are involved in pain control and are the targets of numerous drugs including morphine and its derivatives. The different opioid receptors are widely and differentially distributed throughout the human central nervous system and peripheral tissues [1]. Molecular studies revealed that MOR and DOR are highly expressed in brain regions with subtle differences; DOR are found at higher levels compared to MOR in cerebral cortex, putamen, nucleus accumbens, caudate nucleus, temporal lobe, and hippocampus. The cerebral distribution of DOR is in agreement with their involvement in motor as well as in cognitive functions. In contrast, higher levels of MOR are measured in cerebellum, the spinal cord and dorsal root ganglia suggesting that they may play an important role in the control of nociception. KOR are expressed in different brain regions although at moderate amounts and are implicated

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