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Response to Imatinib Mesylate in Patients with Early Chronic Phase Chronic Myeloid Leukemia and Derivative Chromosome 9 Deletion or Clonal Evolution | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2014, Vol 4(3): 166
  • DOI: 10.4172/2161-0681.1000166

Response to Imatinib Mesylate in Patients with Early Chronic Phase Chronic Myeloid Leukemia and Derivative Chromosome 9 Deletion or Clonal Evolution

Mohammad Usman Shaikh1*, Tariq Moatter2, Naveen Naz Syed3, Natasha Ali4 and Salman Naseem Adil1
1Department of Pathology and Microbiology, Section of Hematology, The Aga Khan University Hospital, Karachi, Pakistan
2Department of Molecular Pathology, Section of Molecular Pathology, The Aga Khan University Hospital, Karachi, Pakistan
3Department of Pathology, King Saud bin Abdul Aziz University of Health Sciences, Riyadh, Saudi Arabia
4Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan
*Corresponding Author : Mohammad Usman Shaikh, Department of Pathology and Microbiology, The Aga Khan University Hospital, P.O Box 3500, Stadium Road, Karachi – 74800, Pakistan, Tel: 92-21-34861303, Fax: 92-21-34934294, Email: [email protected]

Received Date: Sep 17, 2013 / Accepted Date: Mar 29, 2014 / Published Date: Apr 02, 2014


Objectives: The significance of clonal evolution and derivative chromosome 9 in Philadelphia-positive CML is not fully characterized and studies have yielded conflicting results. After working on emergence of clonal evolution from our region, we continued to find out the response of Imatinib Mesylate on such cases of CML treated in our center.
Materials and methods: We conducted a cross sectional, prospective analysis on response of Imatinib Mesylate on patients with Philadelphia positive chronic myeloid leukemia with clonal evolution treated from period of September 2007 till 2010. Patients were grouped on basis of cytogenetic analysis performed by conventional cytogenetic and fluorescence in situ hybridization (FISH) techniques and followed for three years to see the response rate of imatinib mesylate.
Results: We reported here the response rate in one hundred and two previously untreated cases of chronic myeloid leukemia (Philadelphia positive). Twelve patients (11.7%) exhibit derivative chromosome 9, three had trisomy 8, one with addition 15 and one had deletion 16. At follow-up of 30 months 78 cases were evaluable and 45% and 61% showed complete and major cytogenetic response respectively. There is no significant association of derivative chromosome 9 with the response of imatinib mesylate in our group.
Conclusion: Imatinib mesylate is the first line therapy in chronic phase of CML but the role in patients with clonal evolution need to be established by larger group of patients.

Keywords: CML; Cytogenetics; Imatinib mesylate

Citation: Shaikh MU, Moatter T, Syed NN, Ali N, Adil SN (2014) Response to Imatinib Mesylate in Patients with Early Chronic Phase Chronic Myeloid Leukemia and Derivative Chromosome 9 Deletion or Clonal Evolution. J Clin Exp Pathol 4:166. Doi: 10.4172/2161-0681.1000166

Copyright: © 2014 Shaikh, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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