alexa Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Clin Exp Pathol 2018, Vol 8(3): 346
  • DOI: 10.4172/2161-0681.1000346

Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats

Marwa Fouad Hassa1*, Samy Hussein2, Yakout El Senosi2, Mogda Kamal Mansour1 and Aziza Amin2
1Animal Health Research Institute (AHRI), Dokki, , Egypt
2Faculty of Veterinary Medicine, Benha University, Egypt
*Corresponding Author : Marwa Fouad Hassa, Animal Health Research Institute (AHRI), Dokki, Egypt, Tel: 0100608248, Email: [email protected]

Received Date: May 04, 2018 / Accepted Date: May 26, 2018 / Published Date: Jun 02, 2018

Abstract

The aim of the present study was to evaluate the possible protective effects of ginger, an anti-inflammatory agent, against metalaxyl induced liver toxicity in male rats. In total, 42 albino rats were fed a standard rodent diet and divided into 3 equal groups. Group I (normal control group): rats administered distilled water. Group II (metalaxyl exposed group): rats received 1/10 LD50 (130 mg/kg b.wt) orally three times per weeks for 8 weeks. Group III (metalaxyl+ginger treated group): rats received metalaxyl (130 mg/kg b.wt) and treated with ginger (100 mg/kg b.wt/day/orally). Metalaxyl caused significant increase in liver tissue nitric oxide (NO) and L-Malondialdehyde L-MDA levels associated with upregulation of nuclear factor kappa B (NF-kB), tumor necrosis factor alpha (TNF-α) and Caspase-8 gene expression and increase DNA damage in liver tissue while down-regulation in Peroxisome proliferator activated receptor alpha PPAR-α. In addition, the results demonstrated that ginger might ameliorate metalaxyl-induced liver damage by decreasing oxidative stress. Moreover, ginger exhibited protective action against the metalaxyl-induced histopathological and immunohistochemical changes in liver tissues of male rats. In conclusion, ginger was found to be effective in protecting rats against metalaxyl-induced liver damage by anti-inflammatory mechanism.

Keywords: Metalaxyl; Ginger; Oxidative stress; Pro-inflammatory cytokines; apoptosis

Citation: Hassa MF, Hussein S, Senosi YEl, Mansour MK, Amin A (2018) Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats. J Clin Exp Pathol 8:346. Doi: 10.4172/2161-0681.1000346

Copyright: © 2018 Hassa MF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 504
  • [From(publication date): 0-2018 - Mar 27, 2019]
  • Breakdown by view type
  • HTML page views: 467
  • PDF downloads: 37
Leave Your Message 24x7
Top