Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats
Received Date: May 04, 2018 / Accepted Date: May 26, 2018 / Published Date: Jun 02, 2018
The aim of the present study was to evaluate the possible protective effects of ginger, an anti-inflammatory agent, against metalaxyl induced liver toxicity in male rats. In total, 42 albino rats were fed a standard rodent diet and divided into 3 equal groups. Group I (normal control group): rats administered distilled water. Group II (metalaxyl exposed group): rats received 1/10 LD50 (130 mg/kg b.wt) orally three times per weeks for 8 weeks. Group III (metalaxyl+ginger treated group): rats received metalaxyl (130 mg/kg b.wt) and treated with ginger (100 mg/kg b.wt/day/orally). Metalaxyl caused significant increase in liver tissue nitric oxide (NO) and L-Malondialdehyde L-MDA levels associated with upregulation of nuclear factor kappa B (NF-kB), tumor necrosis factor alpha (TNF-α) and Caspase-8 gene expression and increase DNA damage in liver tissue while down-regulation in Peroxisome proliferator activated receptor alpha PPAR-α. In addition, the results demonstrated that ginger might ameliorate metalaxyl-induced liver damage by decreasing oxidative stress. Moreover, ginger exhibited protective action against the metalaxyl-induced histopathological and immunohistochemical changes in liver tissues of male rats. In conclusion, ginger was found to be effective in protecting rats against metalaxyl-induced liver damage by anti-inflammatory mechanism.
Keywords: Metalaxyl; Ginger; Oxidative stress; Pro-inflammatory cytokines; apoptosis
Citation: Hassa MF, Hussein S, Senosi YEl, Mansour MK, Amin A (2018) Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats. J Clin Exp Pathol 8:346. Doi: 10.4172/2161-0681.1000346
Copyright: © 2018 Hassa MF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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