Abstract

In-silico modeling is increasingly being used for simulation of adsorption, distribution, metabolization, and excretion to predict the curve of plasma levels and bioavailabilityof oral drug formulations. Computational models for the prediction of other application routes are less common. Preliminary data shows that GastroPlus^TM simulation software appears suitable for prediction of drug plasma levels of inhaled drugs in healthy individuals. Since also the influence of physiological variations on lung deposition can be simulated, this software could be a valuable tool in the screening of promising formulations.

Keywords: In-silico modeling; Gastroplus™; Budesonide; Turbohaler