alexa Salivary Duct Carcinoma in Minor Salivary Glands: Report of Two Cases with Different Clinical Behavior
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Case Report

Salivary Duct Carcinoma in Minor Salivary Glands: Report of Two Cases with Different Clinical Behavior

Rogério O. Gondak1*, Fernanda V. Mariano2, Fabio A. Alves3, Oslei P. Almeida3 and Márcio A. Lopes4

1Department of Pathology, Federal University of Santa Catarina, Brazil

2Division of Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Brazil

3Department of Stomatology, A. C. Camargo Cancer Hospital, Brazil

4Department of Oral Diagnosis, University of Campinas, Brazil

*Corresponding Author:
Rogério O. Gondak
Department of Pathology, Federal University of Santa Catarina
Delfino Conti Street s/n, Florianópolis, SC. CEP 88040-900, Brazil
Tel: 554837213482
E-mail: [email protected]

Received Date: January 16, 2014; Accepted Date: March 14, 2014; Published Date: March 19, 2014

Citation: Gondak RO, Mariano FV, Alves FA, Almeida OP, Lopes MA (2014) Salivary Duct Carcinoma in Minor Salivary Glands: Report of Two Cases with Different Clinical Behavior. J Clin Exp Pathol 4:164. doi: 10.4172/2161-0681.1000164

Copyright: © 2014 Gondak RO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Salivary duct carcinoma (SDC) is a malignant epithelial tumor extremely rare in minor salivary glands. This manuscript describes two cases of SDC of the minor salivary glands with different clinical behaviors. The first patient was an 80-year-old man who had SDC (T1N0M0) in the upper buccal fornix and the second patient was a 64-yearold man with a tumor (T2N2cM0) in the soft palate. Patients were treated with radical surgical resection and none patient underwent postoperative radiotherapy or chemotherapy. Histopathologically, the lesions showed proliferation of ductal cells with varying degrees of nuclear pleomorphism arranged in solid and cribriform structures and prominent comedonecrosis. The patient with SDC in the soft palate developed metastases and died shortly after diagnosis while the patient with SDC in upper alveolar ridge is alive without disease for over 6 years of follow-up. Although SDC is aggressive, anatomical site and precocious diagnosis are relevant factors for better prognosis.


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