Secondary Haemophagocytosis in a Patient with Ewing's Sarcoma | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Case Report   
  • J Clin Exp Pathol 2014, Vol 4(1): 151
  • DOI: 10.4172/2161-0681.1000151

Secondary Haemophagocytosis in a Patient with Ewing's Sarcoma

Natasha Ali* and Huma Mansoori
Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
*Corresponding Author : Natasha Ali, Department of Pathology and Microbiology, The Aga Khan University Hospital, P.O. Box 3500, Karachi-74800, Pakistan, Tel: +92-21-34861306, Fax: +92-21-34934294, Email: [email protected]

Received Date: Sep 17, 2013 / Accepted Date: Nov 22, 2013 / Published Date: Nov 25, 2013


Secondary haemophagocytosis in malignant tumours have been reported in bone marrow. However we present engulfment of malignant apoptotic Ewing’s sarcoma cells by macrophages in the bone marrow. A 24 year old Pakistani male patient presented with complains of backache. After imaging, a laminectomy was performed the biopsy results of which were consistent with Ewing’s sarcoma. Subsequently for staging, bone marrow and trephine was done. The bone marrow aspirate showed markedly increased haemophagocytic activity with histiocytes engulfing malignant apoptotic Ewing’s sarcoma cells. The presence of histiocytes engulfing apoptotic Ewing’s sarcoma cells was of particular interest. Similar findings have rarely been reported.

Keywords: Bone marrow; Haemophagocytosis; Ewing’s sarcoma

Citation: Ali N, Mansoori H (2013) Secondary Haemophagocytosis in a Patient with Ewing’s Sarcoma. J Clin Exp Pathol 4:151. Doi: 10.4172/2161-0681.1000151

Copyright: © 2013 Ali N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.