alexa Sphingosine 1 Phosphate in Cell Signaling with Emphasis
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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Review Article

Sphingosine 1 Phosphate in Cell Signaling with Emphasis in Protozoan Infections

Carolina López-Guzmán1, Jaime Carmona-Fonseca2and Amanda Maestre3*

1Carolina López-Guzmán, Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia

2Jaime Carmona-Fonseca, Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia

3Amanda Maestre, Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia

*Corresponding Author:
Amanda Maestre
Grupo Salud y Comunidad, Facultad de Medicina
Universidad de Antioquia, Medellín
Carrera 51 D Numero 62-29
office 303, Colombia
Tel: 574 219 6024
Fax: 574 219 6000
E-mail: [email protected]

Received Date: February 24, 2014; Accepted Date: April 03, 2015; Published Date: April 07, 2015

Citation: López Guzmán C, Carmona Fonseca J, Maestre A (2015) Sphingosine 1 Phosphate in Cell Signaling with Emphasis in Protozoan Infections . J Clin Exp Pathol 5:222. doi: 10.4172/2161-0681.1000222

Copyright: ©2015 Zhou W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Problem: Protozoan infections represent a serious public health problem requiring novel approaches from the basic science perspective. Sphingosine 1 phosphate (S1P), is an important component of plasma membrane and, in protozoan infections, a role in infection persistence has been noted. The aim of this review is to summarize the current knowledge about sphingolipids (SL), specifically S1P, and their involvement in protozoan infections such as malaria. Methodology: A non-systematic review in the databases Pubmed, Embase, Free Medical Journals, and Lilacs databases was performed using the following keywords: sphingosine 1 phosphate, malaria, protozoa infections, sphingolipids, S1P receptor (S1PR), immunity, receptors, signaling. The search was limited to articles published between January 1995 and December 2014. Selection of articles to be included was based on relevance to the field of interest, regardless of the language. Results: The number of articles retrieved and those which fulfilled the inclusion criteria were, respectively, 4455 and 143. Conclusions: The role of sphingolipids in protozoan infections is poorly understood, especially in plasmodial infection. S1P might act as immune modulator. SL might be promoters of cell invasion and pathology. They also exhibit potential as antimalarials and biomarkers of infection.

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