ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Chem Biol Ther 2016, Vol 1(2): 110
  • DOI: 10.4172/2572-0406.1000110

Stromal Derived Factor 1 alpha (SDF-1a) in a Dual Therapy with the DPP-4 Inhibitor 1 Vildagliptin does not Enhance Beta Cell Function but Improves Glucose Clearance after Oral Glucose in Streptozotocin Diabetic Mice

Omara B1, Liehuaa L2 and Ahrén B1*
1Department of Clinical Sciences Lund, Lund University, Lund, Sweden
2The First Affiliated Hospital of Sun Yat-sen University, , Guangzhou 510080, China
*Corresponding Author : Ahrén B, Department of Clinical Sciences Lund, Lund University, Sölvegatan 19, Lund, Sweden, Tel: 46462220758, Email: Bo.Ahren@med.lu.se

Received Date: Jul 19, 2016 / Accepted Date: Sep 19, 2016 / Published Date: Sep 23, 2016

Abstract

Pancreatic alpha cells secrete glucagon-like peptide 1 (GLP-1), the production of which is enhanced by the chemokine stromal derived factor 1 (SDF-1). Since SDF-1, like GLP-1, is a substrate of dipeptidyl peptidase-4 (DPP-4), we examined whether dual therapy with SDF-1 and a DPP-4 inhibitor would preserve beta cell function and mass in diabetes. Diabetes was induced by daily injections of streptozotocin for 5 days. One diabetic group was treated with daily injections of SDF-1 alpha or vehicle for 5 days. These mice were concurrently treated with either the DPP-4 inhibitor vildagliptin or vehicle and they remained on vildagliptin or vehicle for an additional 3 weeks. Glucose clearance and beta cell function was evaluated from glucose and insulin data during OGTTs performed after 0, 2 and 4 weeks of treatment. Beta cell mass was determined histologically. Body weight did not differ between diabetic groups during the study. OGTT data showed that diabetic mice treated with SDF-1 alpha in combination with vildagliptin had increased glucose clearance which was not observed with vildagliptin alone. In contrast, vildagliptin alone enhanced beta cell function with no further enhancement by the combination with SDF-1 alpha. Beta cell mass and islet GLP-1 content were not altered by the treatments. In conclusion, SDF-1 alpha and vildagliptin combination therapy improves glucose clearance in streptozotocin induced diabetes in the mouse by an effect which seems independent from enhanced beta cell function.

Keywords: Glucose; Insulin; GLP-1; SDF-1; DPP-4; Diabetes

Citation: Omara B, Liehuaa L, Ahrén B (2016) Stromal Derived Factor 1 alpha (SDF-1a) in a Dual Therapy with the DPP-4 Inhibitor 1 Vildagliptin does not Enhance Beta Cell Function but Improves Glucose Clearance after Oral Glucose in Streptozotocin Diabetic Mice. J Chem Biol Ther 2: 110. Doi: 10.4172/2572-0406.1000110

Copyright: © 2016 Omara B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top