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Targeting Soluble Epoxide Hydrolase for Temporal Lobe Epilepsy | OMICS International| Abstract

Journal of Clinical & Experimental Neuroimmunology
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  • Review Article   
  • J Clin Exp Neuroimmunol 2016:109,

Targeting Soluble Epoxide Hydrolase for Temporal Lobe Epilepsy

Yu-Wen Hung1,2 and Yung-Yang Lin1,2,3,4,5,6,7*
1Institute of Brain Science, National Yang Ming University, Taipei, Taiwan
2Laboratory of Neurophysiology, Department of Medical Research, Taipei Veterans General Hospital, , Taipei, Taiwan
3Brain Research Center, National Yang Ming University, Taipei, Taiwan
4School of Medicine, National Yang Ming University, Taipei, Taiwan
5Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
6Section of Cerebrovascular Diseases, Neurological Institute, Taipei Veterans General Hospital, , Taipei, Taiwan
7Department of Neurology, the Neurological Institute, Taipei Veterans General Hospital, , Taipei, Taiwan
*Corresponding Author : Yung-Yang Lin, Institute of Brain Science, National Yang Ming University, No.155, Sec.2, Linong Street, Taipei, 112, Taiwan, Tel: 886-2-28757398, Email: [email protected], [email protected]

Received Date: Jun 08, 2016 / Accepted Date: Jul 05, 2016 / Published Date: Jul 11, 2016

Abstract

Epilepsy is a common brain disorder characterized by a chronic predisposition to generate spontaneous seizures. It remains unknown regarding the mechanisms for epilepsy formation. Prolonged seizures trigger significant neuroinflammatory responses in experimental and human temporal lobe epilepsy, which have been speculated to be mediating the epileptogenesis. Currently, extensive evidence suggests that anti-inflammatory approaches might offer a promising alternative therapeutic strategy especially when antiepileptic medications are ineffective. By diminishing the anti-inflammatory activities of epoxyeicosatrienoic acids (EETs), soluble epoxide hydrolase (sEH) has been considered a potential therapeutic target for epileptic seizures. Here we review evidences concerning the relevance of neuroinflammarion to the pathophysiology of epilepsy, the physiological functions of EETs-sEH metabolism in central nervous system, and the linkage of EET-sEH pathway to neuroinflammation and neuromodulation. Several contemporary studies have contributed to defining the importance of sEH inhibition in modulating inflammatory responses and abnormal hyperexcitability related to epilepsy. Notwithstanding some discrepancies have been noted between different experimental models or between pharmacological inhibition and genetic deletion of sEH, the involvement of sEH in the generation and progression of epilepsy suggests that sEH may be an attractive target for therapeutic intervention.

Keywords: Soluble epoxide hydrolase; Epoxyeicosatrienoic acids; Epilepsy; Neuroinflammation; Brain hyperexcitability

Citation: Wen Hung Y, Lin YY (2016) Targeting Soluble Epoxide Hydrolase for Temporal Lobe Epilepsy. J Clin Exp Neuroimmunol 1:109.

Copyright: ©2016 Wen Hung Y et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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