The Clinical Value of Abnormal TBX15 Hypermethylation in HCC | OMICS International| Abstract

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  • Research Article   
  • J Oncol Res Treat,
  • DOI: 10.4172/aot.s4.1000002

The Clinical Value of Abnormal TBX15 Hypermethylation in HCC

Sarah Mansouri1, Hai Zhu2, Hai Yang Xie and Jia Lin Liu3*
1Health Science Center, Shenzhen University, Shenzhen, Guangdong, China
2The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
3Department of Hepatobiliary and Pancreatic Surgery, Shenzhen Traditional Chinese Medicine Hospital, No.1 Fuhua Road, Shenzhen, Guangdong, 518000, China
*Corresponding Author : Jia Lin Liu, Department of Hepatobiliary and Pancreatic Surgery, Shenzhen Traditional Chinese Medicine Hospital, No.1 Fuhua Road, Shenzhen, Guangdong, 518000, China, Email: [email protected]

Received Date: Aug 05, 2021 / Accepted Date: Aug 19, 2021 / Published Date: Aug 26, 2021


Background: HCC is one of the most common and invasive malignant tumors in the world. The objective of this research was to explore the methylation of TBX15 and determine the clinical value of TBX15 Hypermethylation in Hepatocellular Carcinoma (HCC).

Methods: The methylation status of the TBX15 gene in 61 pairs of HCC patient tumor and paracancerous tissues was analyzed with bisulfite and methylation-specific PCR, and the association between TBX15 Hypermethylation and specific clinical features was determined.

Results: TBX15 Hypermethylation was associated with patient prognosis. Eighty percent of the tumor and associated paracancerous tissues were hypermethylated. The methylation levels of TBX15 in all 61 tumors were higher than those in the paired paracancerous tissues. The difference between the two tissue types was statistically significant (P<0.001). The methylation level of TBX15 was increased in tumor tissues with vascular invasion (P>0.05) and poor envelope integrity (P<0.05). Additionally, Hypermethylation of TBX15 was statistically associated with advanced cancer stage (P<0.05). The Area Under the Curve (AUC) value (0.98) indicated that TBX15 Hypermethylation had a high confidence value for diagnosing HCC. The Kaplan-Meier analysis suggested that TBX15 Hypermethylation was associated with low relapse-free survival rates. The Cox proportional hazards regression analysis indicated that TBX15 Hypermethylation was an independent factor affecting prognosis.

Conclusion: TBX15 Hypermethylation was related to malignant behavior and was identified as a potential indicator for poor prognosis. Therefore, TBX15 Hypermethylation can be used as a biomarker for the diagnosis and prognostication of HCCs.

Keywords: TBX15; DNA hypermethylation; Hepatocellular carcinoma; Biomarker; Hepatology

Citation: Zhang RK, Zhu H, Xie HY, Liu JL (2021) The Clinical Value of Abnormal TBX15 Hypermethylation in HCC. J Oncol Res Treat S4: 002. Doi: 10.4172/aot.s4.1000002

Copyright: © 2021 Zhang RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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