Abstract

Transfusion medicine has undergone significant advancements since its inception, particularly in response to the challenges posed by infectious diseases. This historical review examines key milestones in transfusion practices, focusing on the impact of infectious agents such as HIV, hepatitis viruses, and West Nile virus on blood safety protocols. By analyzing past experiences and developments in screening, testing, and pathogen inactivation technologies, we identify lessons learned that continue to inform contemporary practices. Additionally, we explore future implications for transfusion medicine, including the integration of advanced technologies and personalized medicine approaches to enhance safety and efficacy. This review emphasizes the ongoing need for vigilance in blood safety and highlights the importance of continuous research and innovation in transfusion medicine.