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Hindi The Future of Dementia Pathology: A Comprehensive Review on Trends and Innovations
*Corresponding Author:Received Date: May 30, 2024 / Published Date: Jun 09, 2025
Citation: Connell N, Carter T, Taylor A, Chandler M (2025) The Future of Dementia Pathology: A Comprehensive Review on Trends and Innovations. J Alzheimers Dis Parkinsonism 15: 633.
Copyright: © 2025 Connell N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Dementia encompasses a range of neurodegenerative disorders characterized by a progressive decline in cognitive function, impacting memory, thinking, orientation, comprehension, language and judgment. This review examines the pathology of major dementias: Alzheimer's Disease (AD), vascular dementia, Lewy Body Dementia (LBD), Frontotemporal Dementia (FTD) and rarer types like Huntington's disease and Creutzfeldt-Jakob disease. Each type features unique pathological markers-amyloid plaques and neurofibrillary tangles in AD, vascular lesions in vascular dementia, Lewy bodies in LBD, and various proteinopathies in FTD. Shared mechanisms include protein misfolding, neuroinflammation, synaptic dysfunction and mitochondrial impairment. Advances in neuroimaging, cerebrospinal fluid biomarkers and genetic testing have improved diagnostics. While current treatments focus on symptom management, research into disease-modifying therapies is crucial. Preventive strategies, such as lifestyle modifications and cardiovascular risk management, are essential for reducing dementia risk. Continued research is vital for developing targeted treatments and improving patient outcomes through early diagnosis and intervention.
