Abstract

Bilobalide (BB), a sesquiterpene isolated from Ginkgo biloba extract, has attracted great interest as a potential therapeutic agent for several neurological diseases. Multiple Sclerosis (MS) is a chronic immune-mediated inflammatory and neurodegenerative disease of the Central Nervous System (CNS), which results in demyelination and axonal degeneration. Experimental Autoimmune Encephalomyelitis (EAE), characterized by infiltration of T cells and macrophages, neuroinflammation and severe demyelination, is the best imitation and extensively used to study MS. The recent paper, “The therapeutic potential of bilobalide on Experimental Autoimmune Encephalomyelitis (EAE) mice”, provides evidence that BB protected myelin sheath by immunomodulatory, anti-inflammation and antiapoptosis. In this review, we discussed the findings of BB treatment on EAE.

Keywords: Bilobalide; Neuroprotection; Immunomodulatory; Anti-inflammation; Anti-apoptosis