The Implications of SFRP2 Gene Hypermethylation in Colorectal Cancer
Received Date: Dec 24, 2022 / Published Date: Apr 06, 2023
Abstract
Background: The Wnt pathway is stimulated by the DNA hypermethylation of SFRP2, which inhibits gene activity, downregulates the gene expression and promotes CRC.
Objectives: This study aims to assess the prognostic impact of hypermethylation of SFRP2 in colorectal cancer.
Methodology: The research used twenty (20) blood samples from patients with colorectal cancer detected at Sher-I-Kashmir institute of medical sciences as well as thirty (30) patients with histologically confirmed colorectal cancer who underwent surgical excision in the department of general surgery. Methylation Specific PCR (MSP) was employed to assess SFRP2 methylation and the results were correlated with several investigated clinicopathological characteristics.
Results: Our results showed that SFRP2 methylation levels are significantly present in tumor tissues and blood samples as compared to normal counterparts.
Conclusion: We infer that the hypermethylation of the SFRP2 promoter in colorectal tumors may contribute to the development of cancer in normal colon and rectum cells.
Keywords: SFRP2; Methylation; Methylation Specific PCR (MSP); Clinicopathological; Hypermethylation
Citation: Ahmad S, Rashid G, Niyaz M, Nisar S, Mudassar S (2023) The Implications of SFRP2 Gene Hypermethylation in Colorectal Cancer. J Oncol Res Treat 8: 222.
Copyright: © 2023 Ahmad S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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