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The Prognostic Influence of CD44 in Oral Squamous Cell Carcinoma | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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  • Review Article   
  • J Clin Exp Pathol 2014, Vol 4(3): 175
  • DOI: 10.4172/2161-0681.1000175

The Prognostic Influence of CD44 in Oral Squamous Cell Carcinoma

Lucinei Roberto Oliveira1*, Andrielle Castilho-Fernandes2 and Alfredo Ribeiro-Silva3
1Department of Pathology, Vale do Rio Verde University (UninCor), Tres Coraçoes-MG, Brazil
2Departamento de Química, Centro de Nanotecnologia e Engenharia de Tecidos, Universidade de São Paulo, Brazil
3Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto-SP, Brazil
*Corresponding Author : Lucinei Roberto Oliveira, Vale do Rio Verde University (UninCor), Avenida Castelo Branco 82, Tres Coraçoes, Minas Gerais, Brazil, Tel: 55 35 3239 1280, Fax: 55 35 3239 1280, Email:

Received Date: Apr 23, 2014 / Accepted Date: May 24, 2014 / Published Date: May 27, 2014


Oral Squamous Cell Carcinoma (OSCC) is the most frequent malignant tumor of the oral cavity, exhibiting a heterogeneous behavior. Because the mortality rate for this tumor has essentially remained unchanged over the last few decades, the need exists for more reliable prognostic factors in OSCC. The objective of this review was to examine the relevance of CD44 expression on the prognosis of OSCC patients through a critical analysis of the most significant current scientific literature on this subject. We found that most investigations of CD44 expression in OSCC over the years have demonstrated some prognostic influence, although there were significant differences among the studies. Certain studies have also demonstrated that CD44 may be an important biomarker of Cancer Stem Cells (CSCs) in OSCC. However, as with the discrepancies regarding the true prognostic value of CD44 in OSCC, some studies have indicated that CD44 might be limited in the identification of oral CSCs. Thus, according to our findings, additional and more standardized research should be conducted to validate the CD44 molecule as a reliable biomarker of prognosis and of CSCs in OSCC.

Keywords: Oral cancer; CD44; Cancer stem cells; Prognosis

Citation: Oliveira LR, Castilho-Fernandes A, Ribeiro-Silva A (2014) The Prognostic Influence of CD44 in Oral Squamous Cell Carcinoma. J Clin Exp Pathol 4:175. Doi: 10.4172/2161-0681.1000175

Copyright: © 2014 Oliveira LR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.