Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function
Received Date: Mar 25, 2021 / Accepted Date: Apr 08, 2021 / Published Date: Apr 15, 2021
Abstract
Mesenchymal Stromal Cell(MSC) therapies to modulate inflammation and promote tissue regeneration in Recessive Dystrophic Epidermolysis Bullosa(RDEB) are under active investigation in clinical trials. However, optimal tissue source and fundamental mechanisms of clinical benefit of MSCs require additional investigation. Riedl et al.recently published “ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and localimmunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment,” in Stem Cells [1] highlightingdifferences in homing of MSCs, impact on local macrophages, and distinct transcriptional profiles related to tissue oforigin (skin dermis versus bone marrow). Elucidation of these critical features and underlying mechanisms will aid intranslation of MSC cellular therapies to promote wound healing in RDEB.
Keywords: Mesenchymal Stromal Cell; Recessive DystrophicEpidermolysis Bullosa; Mesenchymal Stromal Cells; Bone Marrow
Citation: Ebens CL, Riedl JA, Tolar J (2021) Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function. J Oncol Res Treat S1:001. Doi: 10.4172/aot.s1.1000001
Copyright: © 2021 Ebens CL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Licenpsee,r mwithsich unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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