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Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • J Oncol Res Treat,
  • DOI: 10.4172/aot.s1.1000001

Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function

Christen L. Ebens1*, Julia A. Riedl2 and Jakub Tolar2,3
1Department of Pediatrics, Division of Blood & Marrow Transplant and Cellular Therapy, University of Minnesota, Minneapolis, MN, USA
2Medical Scientist Training Program, University of Minnesota, Minneapolis, MN, USA
3Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
*Corresponding Author : Christen L. Ebens, Division of Blood & Marrow Transplant and Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA, Tel: 612-626-8094, Fax: 612-626-2815, Email: [email protected]

Received Date: Mar 25, 2021 / Accepted Date: Apr 08, 2021 / Published Date: Apr 15, 2021

Abstract

Mesenchymal Stromal Cell(MSC) therapies to modulate inflammation and promote tissue regeneration in Recessive Dystrophic Epidermolysis Bullosa(RDEB) are under active investigation in clinical trials. However, optimal tissue source and fundamental mechanisms of clinical benefit of MSCs require additional investigation. Riedl et al.recently published “ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and localimmunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment,” in Stem Cells [1] highlightingdifferences in homing of MSCs, impact on local macrophages, and distinct transcriptional profiles related to tissue oforigin (skin dermis versus bone marrow). Elucidation of these critical features and underlying mechanisms will aid intranslation of MSC cellular therapies to promote wound healing in RDEB.

Keywords: Mesenchymal Stromal Cell; Recessive DystrophicEpidermolysis Bullosa; Mesenchymal Stromal Cells; Bone Marrow

Citation: Ebens CL, Riedl JA, Tolar J (2021) Tissue-Specific Differences in Mesenchymal Stromal Cells Influence Homing and Function. J Oncol Res Treat S1:001. Doi: 10.4172/aot.s1.1000001

Copyright: © 2021 Ebens CL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Licenpsee,r mwithsich unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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