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To Investigate Role of Glycosylated Hemoglobin (Hba1c) as a Biomarker for Prediction of Dementia and Cognitive Dysfunction in Type 2 Diabetic Patients| Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(2): 437
  • DOI: 10.4172/2161-0460.1000437

To Investigate Role of Glycosylated Hemoglobin (Hba1c) as a Biomarker for Prediction of Dementia and Cognitive Dysfunction in Type 2 Diabetic Patients

Aman Gupta1*, Abha Singh2, Ramesh C.Deka3, Rakesh Gupta4 and Ritu Jha5
1Amity Institute of Neuropsychology and Neurosciences, Amity University, Uttar Pradesh, Noida, India
2Amity Institute of Psychology and Allied Sciences, Amity University, Uttar Pradesh, Noida, India
3Chair Professor of Medical Education & Research and Director general of Public Health Studies, Amity University, Uttar Pradesh, India
4Department of Internal Medicine, Sarvodaya Hospital and Research Center, , Faridabad, Delhi NCR, India
5Department of Neurology, Sarvodaya Hospital and Research Center, , Faridabad, Delhi NCR, India
*Corresponding Author : Aman Gupta PhD, Research Scholar, Amity Institute of Neuropsychology and Neurosciences, Amity University, Uttar Pradesh, Noida, India, Tel: 911294013135, Email: [email protected]

Received Date: May 11, 2017 / Accepted Date: Apr 04, 2018 / Published Date: Apr 11, 2018

Abstract

Introduction: Diabetes Mellitus is one the major disease burden globally. One of the significant complications of the uncontrolled Diabetics is Cognitive dysfunction and Dementia. In this study we laid focus on the Evaluation of HbA1C as a Biomarker to predict Dementia and Cognitive Dysfunction in Type 2 Diabetic Mellitus. Aim of the study: A pilot study to investigate HbA1C as a Biomarker for prediction of Dementia and Cognitive Dysfunction in Type 2 Diabetic Mellitus in a Hospital Setting. Methods and results: A prevalence study in which 60 subjects (n=30 Type 2 Diabetics; n=30 non Diabetic) were enrolled. In this study HbA1C values were correlated with that of individual memory and cognition batteries* score. The range of the HbA1C values was 7.1 to 13.3. The mean values of HbA1C in the Diabetic group (n=30) was found to be 9.19.The corresponding values of Pearson’s Correlation “r” in the diabetic group of the w.r.t. various Cognitive batteries were: General Practitioner Assessment of Cognition (GPCOG)=-0.53; Attendant Informant Tool (AI)=-0.43; Memory Impairment Screen (MIS)=-0.37; Negative values of the Pearson’s Correlation “r” indicates that lower the respective battery score, poorer is the cognitive function. In the Diabetic group GPCOG, AI and MIS were found to be significantly correlated with HBA1C. Similarly, in the non- Diabetic group (n=30), no significant Dementia and Cognitive Impairment was recorded when same group of Cognitive Batteries were administered. Conclusion: It is quite evident from the results that HbA1C as biomarker has a great potential to predict Dementia and Cognitive decline in uncontrolled Diabetes. However, the study needs to be conducted on a larger scale along with comparative analysis with tools like Functional MRI and other standard biomarkers.

Keywords: Diabetes; Dementia; Alzheimers

Citation: Gupta A, Singh A, Deka RC, Gupta R, Jha R (2018) To Investigate Role of Glycosylated Hemoglobin (Hba1c) as a Biomarker for Prediction of Dementia and Cognitive Dysfunction in Type 2 Diabetic Patients. J Alzheimers Dis Parkinsonism 8: 437. Doi: 10.4172/2161-0460.1000437

Copyright: © 2018 Gupta A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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