Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment
Received Date: Sep 15, 2017 / Accepted Date: Sep 25, 2017 / Published Date: Sep 29, 2017
Abstract
Cardiac dysrhythmias (atrial and/or ventricular fibrillation) represent a major medical problem, with possibly life-threatening complications, necessitating costly, life-long treatments or complicated procedures. We report here a case of a sustained correction of a severe and long-standing atrial dysrhythmia (hyperexcitability) and at a lesser degree, a ventricular hyperexcitability, occurring after treatment with a combination of sofosbuvir plus ledispavir administered to treat a chronic Hepatitis C virus infection (HCV). The correction appeared within the first days of anti-HCV treatment and was totally maintained 3 months after drug cessation and still noticeable 3 more months. The mechanism of such an antiarrhythmic action has still to be elucidated. If confirmed, the potential antiarrhythmic effect of sofosbuvir combined with another antiviral drug, could represent a real advance in atrial and maybe ventricular hyperexcitability treatment.
Keywords: Cardiac arrhythmia; Atrial fibrillation; Extrasystoles; Sofosbuvir; Ledispavir; HCV
Citation: Slama G, Slama L, Blacher J, Sebbah J, Bèze YE, et al. (2017) Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment. J Chem Biol Ther 2: 114. Doi: 10.4172/2572-0406.1000114
Copyright: © 2017 Slama G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Open Access Journals
Article Tools
Article Usage
- Total views: 8003
- [From(publication date): 0-2017 - Apr 20, 2024]
- Breakdown by view type
- HTML page views: 7202
- PDF downloads: 801
