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Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment | OMICS International| Abstract
ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
Open Access

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  • Case Study   
  • J Chem Biol Ther 2017, Vol 2(1): 114
  • DOI: 10.4172/2572-0406.1000114

Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment

Gérard Slama1,2*, Laurence Slama3, Jacques Blacher1, Joël Sebbah4, Yves El Bèze2, Serge Gryner1 and Stanislas Pol5
1Centre de Diagnostics et de Thérapeutique, AP-HP, Hôtel-Dieu Hospital and Paris Descartes University, , Paris, France
2Centre Médical Bastille, , 5 bis, Place de la Bastille 75004 Paris, France
3Service de Thérapeutique en Immuno-Infectiologie, Hôtel-Dieu Hospital, , Paris, France
4Institut Médical Montsouris, , 42, boulevard Jourdan 75014 Paris, France
5Hepatology Department, Cochin Hospital, Paris Descartes University, Inserm U1223, Institut Pasteur, Paris, France
*Corresponding Author : Gérard Slama MD, Centre de Diagnostics et de Thérapeutique, AP-HP, Hôtel-Dieu Hospital and Descartes University, 85, Avenue Du Général Leclerc 75014, Paris, France, Email: [email protected]

Received Date: Sep 15, 2017 / Accepted Date: Sep 25, 2017 / Published Date: Sep 29, 2017

Abstract

Cardiac dysrhythmias (atrial and/or ventricular fibrillation) represent a major medical problem, with possibly life-threatening complications, necessitating costly, life-long treatments or complicated procedures. We report here a case of a sustained correction of a severe and long-standing atrial dysrhythmia (hyperexcitability) and at a lesser degree, a ventricular hyperexcitability, occurring after treatment with a combination of sofosbuvir plus ledispavir administered to treat a chronic Hepatitis C virus infection (HCV). The correction appeared within the first days of anti-HCV treatment and was totally maintained 3 months after drug cessation and still noticeable 3 more months. The mechanism of such an antiarrhythmic action has still to be elucidated. If confirmed, the potential antiarrhythmic effect of sofosbuvir combined with another antiviral drug, could represent a real advance in atrial and maybe ventricular hyperexcitability treatment.

Keywords: Cardiac arrhythmia; Atrial fibrillation; Extrasystoles; Sofosbuvir; Ledispavir; HCV

Citation: Slama G, Slama L, Blacher J, Sebbah J, Bèze YE, et al. (2017) Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment. J Chem Biol Ther 2: 114. Doi: 10.4172/2572-0406.1000114

Copyright: © 2017 Slama G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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