Abstract

This compilation highlights pivotal advances in translational medicine, focusing on new therapeutic strategies and disease modeling. Key areas include targeting mRNA translation in cancer and utilizing exosome-based drug delivery systems. The field of regenerative medicine is being transformed by human pluripotent stem cells, CRISPR/Cas9 gene editing in induced pluripotent stem cells, and engineering the stem cell microenvironment. Additionally, progress in understanding neurological and inflammatory disorders, particularly involving pyroptosis, is significant. The role of mitochondrial dynamics in metabolic diseases and the revolutionary impact of single-cell multi-omics technologies in uncovering disease mechanisms and guiding personalized therapies are also emphasized. Human stem cell-derived organoids further enhance disease modeling and drug discovery