ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2017, Vol 7(5): 379
  • DOI: 10.4172/2161-0460.1000379

Treatment of the Lesser Ailments of Aging: Phosphodiesterase Type 5 Inhibitors

Charles T Ambrose*
Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
*Corresponding Author : Charles T Ambrose, Department of Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536, USA, Tel: 859 277 3779, Email: cambros@uky.edu

Received Date: Sep 15, 2017 / Accepted Date: Sep 28, 2017 / Published Date: Oct 05, 2017

Abstract

Along with various major illnesses or chronic afflictions, the elderly may also have minor complaints. These include general muscle weakness, cold intolerance; transient memory lapses for a name or word, wrinkled skin, and the slow healing of cuts and bruises. These five symptoms and signs are grouped together here because they may have a common vascular basis, which is the reduction of capillaries throughout the body in the elderly. This reduction is due to diminished levels of angiogenic growth factors, as reported in both aged people and animals. Recombinant forms of these factors given parenterally have elicited capillary production (angiogenesis) in numerous experimental studies and if chronically administered to the elderly, might, in theory, ease their lesser ailments. Angiogenesis has also been elicited in animal tissues by type-5 phosphodiesterase inhibitors - sildenafil (Viagra) and tadalafil (Cialis). These are widely prescribed orally for their vasodilatory effect. Tadalafil is discussed here as a potential proangiogenesis agent for modulating the lesser ailments of aging and possibly influencing the clinical course of senile dementias, such as AD.

Keywords: Lesser ailments; Aging; PDE-5 inhibitors; Angiogenesis; Capillary density

Citation: Ambrose CT (2017) Treatment of the Lesser Ailments of Aging: Phosphodiesterase Type 5 Inhibitors. J Alzheimers Dis Parkinsonism 7: 379. Doi: 10.4172/2161-0460.1000379

Copyright: © 2017 Ambrose CT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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