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Validation of a Screening Test, based on Simultaneous Detection of CEA, CA19-9 and p53, for Fast Diagnosis of Gastric Cancer: A Pilot Study | OMICS International| Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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  • Special Issue Article   
  • J Gastrointest Dig Syst,
  • DOI: 10.4172/2161-069X.1000635

Validation of a Screening Test, based on Simultaneous Detection of CEA, CA19-9 and p53, for Fast Diagnosis of Gastric Cancer: A Pilot Study

Stefan-van Staden RI*, Ilie-Mihai RM, Gheorghe DC and Gurzu S
1Department of Electrochemistry, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania
2Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, Targu-Mures, Romania
3Department of Pathology, Clinical County Emergency Hospital of Targu-Mures, Romania
*Corresponding Author : Stefan-van Staden RI, Department of Electrochemistry, National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania, Email: ralucavanstaden@gmail.com

Abstract

Background: Fast screening tests are a need for fast and early diagnosis of gastric cancer. Method: This study showed the results of validation of a screening test that used eight stochastic sensors as new tools for the identification and quantification of three cancer biomarkers: CEA, CA19-9, and p53. The biomarkers were determined from different biological samples: whole blood, urine, saliva, and fresh tissue. Results: Results obtained using the proposed stochastic sensors were compared with those obtained using the standard methods ELISA (for CEA and CA19-9) and chemiluminescence (for p53). The t-tests shown that there is no significant difference between the results obtained using the proposed tools and the standard methods. Conclusions: The fast screening method based on stochastic sensors can be successfully used for screening tests and fast diagnosis of gastric cancer.

Keywords: Stochastic sensors; Fast screening method; Gastric cancer

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