alexa Valproate Level Variation with Menstrual Cycle Phase in Bipolar Disorder | OMICS International | Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Valproate Level Variation with Menstrual Cycle Phase in Bipolar Disorder

Feng Liu1,2,3*, Rui Zhu2,3, Xiaopeng Deng2,3, Chengguo Peng2,3, Song Qin2,3 and Bo Liu1,2,3
1Medical School, Yangtze University, Jingzhou, Hubei, China
2Jingzhou Mental Health Hospital, Jingzhou, Hubei, China
3Department Institute of Mental Health, Yangtze University, Jingzhou, Hubei, China
*Corresponding Author: Feng Liu, Department Institute of Mental Health, Yangtze University, Jinghzou 433000, Hubei, China, Tel: +86-0716-8252483, Fax: +86-0716-8252415, Email: [email protected]

Received Date: Mar 07, 2020 / Accepted Date: Mar 20, 2020 / Published Date: Mar 27, 2020

Citation: Liu F, Zhu R, Deng X, Peng C, Qin S, Liu B (2020) Valproate Level Variation with Menstrual Cycle Phase in Bipolar Disorder. J Clin Exp Pathol 10: 374.

Copyright: © 2020 Liu F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
To read the full article Peer-reviewed Article PDF image

Abstract

Objectives: The purpose of this study was to investigate the changes in serum valproate (VPA) levels and their relationship to progesterone levels during the menstrual cycles of fertile women.

Materials and methods: Female patients compliant with VPA (n=14) were included in this study. Serum VPA and progesterone levels were measured during two periods, in which progesterone levels may be the lowest (early follicular phase) and the highest (mid luteal phase).

Results: Serum VPA levels were significantly different between the two periods. Serum progesterone levels increased in 64.3% of the sample during menstruation, revealed a noticeable but not significant mean increased. There was no correlation between serum valproate and progesterone levels (r=0.209, p>0.05) in the menstrual phase.

Conclusion: This study shows that serum VPA levels varied greatly during the menstrual cycles. The results of this study also implying that VPA levels may be relationship to sex steroid levels in menstrual cycle. Particularly in cyclic premenstrual exacerbation of affective symptoms, this interaction should be considered in the evaluation of treatment may be beneficial.

Keywords

Recommended Conferences

World Congress on Pathology and Microbiology

Manila, Philippines
Share This Page
Top