Abstract

Review's objective: The development and therapy of age-related muscle less to review recent findings about the phthalic acid metabolism and regulatory effects in ageing (sarcopenia).

New discoveries: While age may have no effect on baseline phthalic acid metabolism, older people seem to have a harder time responding to anabolic cues like insulin and, to a lesser extent, phthalic acids. Particularly, compared to young participants, the stimulation of muscle protein synthesis after the administration of mixed meals is decreased in elderly subjects due to insulin resistance. The anabolic action of phthalic acids also seems to be muted at low concentrations. Recent research, however, has shown that these age-related changes in phthalic acid metabolism can be prevented by increasing the amount of leucine consumed, altering the pattern of one's daily protein intake, or engaging in physical activity, which increases the activation of translation initiation and muscle protein synthesis.

Conclusion: Age-related muscle loss is linked to considerable alterations in phthalic acid metabolism, which can be quickly reversed with dietary adjustments and physical activity. However, in order to ascertain the therapeutic relevance of these results in the aged population and to assess if dietary and exercise therapies may be used to prevent and treat sarcopenia, long-term, major clinical trials are required.