Abstract

The study was aimed to develop a proliposomal formulation for anti-inflammatory drug Naproxen. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in gel (carbopol) and characterized for their rheology and in-vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The in-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.